Intracellular Delivery of Protein Drugs

Intracellular Delivery of Protein Drugs Intracellular protein delivery is a daunting task that is near impossible due to the size and surface charge of proteins. However, protein macromolecule delivery is used in numerous disease states, such as monoclonal antibody therapeutics for cancer, autoimmune diseases, or asthma as well as the delivery of recombinant insulin to […]

Fight or Flight?

Flexible Inhibitory Control of Visually Evoked Defensive Behavior Tis the season for ghosts and ghouls and things that go bump in the night. Fear is a drug many of us seek out whether it’s a scary slasher horror flick fueled by the slow meandering of Michael Meyers or jumping out of a plane with nothing, […]

Closed-loop Neuromodulation

Closed-loop Neuromodulation in an Individual with Treatment-Resistant Depression Meriam-Webster defines depression as feelings of severe despondency and dejection, a severe medical condition in which a person feels very sad, hopeless, and unimportant and is often unable to live normally. In the end, the feelings of dejection and a hopeless existence leads many down the dark […]

L-SOMA Gastric Auto-Injectors

L-SOMA Gastric Auto-Injectors The majority of the world’s population very rarely thinks of the route of administration needed to maximize the efficiency of a drug. You have a headache, swallow a Tylenol, allergies intranasal delivery “snort” Flonase, having an asthma attack inhale Albuterol, or you accidentally bit into a peanut butter cookie thinking it was […]

CRISPR Engineered Bioimplants

CRISPR Engineered Bioimplants Inflammation is a natural and necessary biological process that helps with wound healing as well as combating infection. However, the adage “too much of a good thing” is as relevant in a biological system as in our day-to-day lives. Rheumatoid arthritis (RA) is a chronic inflammatory disease state that primarily affects the […]

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis The future is now … “clustered regularly interspaced short palindromic repeats” and associated Cas9 endonuclease aka CRISPR-Cas9 had its inception in 2012 and a Nobel prize awarded in 2020. CRISPR is a powerful gene-editing technique first discovered in bacteria and adapted for permanent human gene knockout. While […]

Programming Gene Expression in Multicellular Organisms

  Programming Gene Expression in Multicellular Organisms  Bacteria are fascinating little machines. In the past century, we have harnessed the power of bacteria to produce antibiotics, recombinant drugs, and food. We as humans have evolved and lived, sometimes symbiotically, with bacteria, i.e., in the case of intracellular mitochondria and cellular energy production. This same symbiosis […]

Losing Fat Through The Skin

Losing Fat Through the Skin In June, the FDA approved Wegovy for chronic weight management. This subcutaneous injection is the first approved drug for chronic weight management in adults with a high BMI and general obesity since 2014. With 70% of American adults being overweight or obese, there certainly seems to be room for new […]

Development of an Effective Non-Hormonal Female Contraception

Development of an Effective Non-Hormonal Female Contraception Birth control is a universal term that encompasses everything from a physical barrier to the chemical inhibition of ovulation. The most common form of contraception, according to the CDC, is female sterilization. Excluding sterilization, the second and third most common forms of birth control are oral contraceptive pills […]