AI to Solve the Misfolded Protein Riddle

Using AI to Solve the Misfolded Protein Riddle One of the most daunting challenges in drug discovery is finding drugs for proteins that misfold. The primary drug design objective is for a small drug molecules to be able to enter an active site and block an enzyme’s or ion channel’s normal function, inhibiting its action […]

Insulin Delivery Using Stem Cells

New Method for Insulin Delivery Using Stem Cells There are many types of diabetes mellitus including juvenile-onset diabetes (type 1), adult-onset diabetes (type 2), and diabetes during pregnancy (gestational diabetes). The underlying mechanism of all diabetes is dysfunctional or non-existent excretion of insulin from the islet cells of the pancreas or insulin insensitivity at the […]

Takotsubo Syndrome in the United States

Takotsubo Syndrome in the United States Valentine’s Day is a holiday empowered by love, romance, wine, and chocolate with the underlying sentiment of celebrating newfound or long-term romantic relationships. According to Greek mythos, humans were originally created with four arms, four legs, and one head with two faces. Zeus fearing their power split them in […]

Potential Biomarker for Astronauts’ Health?

Potential Biomarker for Astronauts’ Health? The physiological stressors of space flight are a significant obstacle to overcome, especially for the 6-month flight to Mars, as well as the decrease in gravity on the surface of the planet. Therefore, the monitoring of serum biomarkers that are selective and sensitive is a vital tool in making sure […]

Intracellular Delivery of Protein Drugs

Intracellular Delivery of Protein Drugs Intracellular protein delivery is a daunting task that is near impossible due to the size and surface charge of proteins. However, protein macromolecule delivery is used in numerous disease states, such as monoclonal antibody therapeutics for cancer, autoimmune diseases, or asthma as well as the delivery of recombinant insulin to […]

Fight or Flight?

  Flexible Inhibitory Control of Visually Evoked Defensive Behavior Tis the season for ghosts and ghouls and things that go bump in the night. Fear is a drug many of us seek out whether it’s a scary slasher horror flick fueled by the slow meandering of Michael Meyers or jumping out of a plane with […]

Closed-loop Neuromodulation

  Closed-loop Neuromodulation in an Individual with Treatment-Resistant Depression Meriam-Webster defines depression as feelings of severe despondency and dejection, a severe medical condition in which a person feels very sad, hopeless, and unimportant and is often unable to live normally. In the end, the feelings of dejection and a hopeless existence leads many down the […]

L-SOMA Gastric Auto-Injectors

L-SOMA Gastric Auto-Injectors The majority of the world’s population very rarely thinks of the route of administration needed to maximize the efficiency of a drug. You have a headache, swallow a Tylenol, allergies intranasal delivery “snort” Flonase, having an asthma attack inhale Albuterol, or you accidentally bit into a peanut butter cookie thinking it was […]

CRISPR Engineered Bioimplants

CRISPR Engineered Bioimplants Inflammation is a natural and necessary biological process that helps with wound healing as well as combating infection. However, the adage “too much of a good thing” is as relevant in a biological system as in our day-to-day lives. Rheumatoid arthritis (RA) is a chronic inflammatory disease state that primarily affects the […]

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

  CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis The future is now … “clustered regularly interspaced short palindromic repeats” and associated Cas9 endonuclease aka CRISPR-Cas9 had its inception in 2012 and a Nobel prize awarded in 2020. CRISPR is a powerful gene-editing technique first discovered in bacteria and adapted for permanent human gene knockout. […]